Jonas Bergh's Group Karolinska Institutet

Targeting chronic lymphocytic leukemia cells using anti-ROR1

power of 85% when the true response rate was 20%. Approximately 95 patients were expected to yield 62 evaluable patients. Estimates of median progression-free survival (PFS) and OS, deﬁnedintheAppendix(online only),weredetermined using … 2018-05-09 Evidence suggests that 10% to 35% of all patients with TNBC have AR-positive gene expression. 2 A recent study found that the AR is more likely to be co-expressed in ER-positive breast cancer compared with ER-negative breast cancer (56.0% vs 28.1%). 12 Furthermore, AR expression was significantly correlated with decreased DFS in TNBC. Gene expression profiling indicates that TNBC is a heterogeneous disease and at present, there is no targeted therapy available for treatment. Approximately one-third of TNBC expressed androgen receptor (AR) and evaluation of AR-positive TNBC primary tumors shows nuclear localization of AR, an indication of transcriptionally active receptors.

Histological or cytological confirmed, metastatic or unresectable triple-negative breast cancer (TNBC). Comprehensive profiling of androgen receptor-positive (AR+) triple-negative breast cancer (TNBC) patients (pts) treated with standard neoadjuvant therapy (NAT) +/- enzalutamide. Research focusing on the AR pathway is encouraging, as well. Data evaluating enzalutamide (Xtandi) in AR-positive TNBC cell lines show significant activity in a phase 2 study in patients with AR-positive disease, defined as 1% staining or higher, with a clinical benefit rate as a primary end point (NCT01889238). 11 Positive expression of AR in TNBC patients was reported to be associated with worse clinical outcomes, indicating that AR blockade might be a potential endocrine therapy for TNBC .

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mars 2010 Cancerstudier och Forskning i Sverige Sida 3

2019-03-01 · At the 10% cutpoint of AR positive, AR expression was associated with the high pathological grade of TNBC patients . Thus, our results revealed that AR immunoreactivity in at least 1% of tumor cell was considered the most appropriate threshold to define AR positivity.

Bröstcancer - Finska Läkaresällskapet

43 , 44 In this study, of 424 patients with ER/PR‐negative BC, 12% was AR‐positive. The androgen receptor (AR) is a promising therapeutic target for a subset of triple-negative breast cancers (TNBCs) in which AR is expressed. However, the mechanistic action of AR and the degree to which primary and metastatic tumors depend on AR, both before and after conventional treatment, remain to be defined. We discuss preclinical and clinical data for AR+ TNBC, the difficulties in Although AR expression is often associated with a favorable prognosis in ERα-positive (ERα+) BC, many findings suggest that, in some instances, high levels of AR can contribute to the therapy-resistance. Again, in ERα negative BC (ERα-), AR is mainly expressed in tumors with apocrine differentiation and a lower Nottingham grade. In our current study, several patients with strongly AR-expressing tumors developed disease recurrence, consistent with their lack of pCR.

AR expression was higher in normal breast tissue (88 %) and adjacent DCIS (73 % overall). All LN metastases from AR-positive TNBC patients were also AR positive; in addition, no AR-negative TNBC patient had AR-positive LNs. Growing studies demonstrated that Androgen Receptor (AR) has an oncogenic role for the patients with AR-positive Triple Negative Breast Cancer (TNBC). AR antagonists in therapy, such as bicalutamide, completely binds to the AR, increasing AR degradation, thus are investigated for the efficacy of the treatment of patients with AR-positive TNBC Introduction Triple negative breast cancer (TNBC) is a heterogeneous collection of biologically diverse cancers, which contributes to variable clinical outcomes. Previously, we identified a TNBC subtype that has a luminal phenotype and expresses the androgen receptor (AR+). TNBC cells derived from these luminal AR + tumors have high frequency phosphatidylinositol-4,5-bisphosphate 3-kinase Luteolin represses the proliferation of AR-positive TNBCs The expression level of the AR in four TNBC cell lines (MDA-MB-231, MDA-MB-468, BT-20, and BT-549) was assessed by western blotting analysis.
Gamla slaver webbkryss

A phase 1/2 study of once-daily oral VT-464 in patients with advanced androgen receptor (AR) positive triple negative (TNBC) or estrogen receptor (ER) positive breast cancer (BC). [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Phase 1/2 study of oral seviteronel (VT-464), a dual CYP17-lyase inhibitor and androgen receptor (AR) antagonist, in patients with advanced AR positive triple negative (TNBC) or estrogen receptor (ER) positive breast cancer (BC) [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. But research is now focusing on the androgen receptor (AR) in a subset of patients with TNBC who are AR-positive. “There is compelling evidence that the androgen pathway may deliver the next target for drug development,” Traina said, referring to a phase 2 safety and efficacy study evaluating enzalutamide (Xtandi) in this subpopulation (NCT01889238).

[abstract].
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US5585089A - Humanized immunoglobulins - Google Patents

The significance of androgen receptor (AR) expression in triple-negative breast cancer (TNBC) is unclear, and published studies so far have been inconclusi 2018-01-31 · However, molecular assays of TNBC have identified distinct subsets of TNBC that may inform therapeutic strategies.

AstraZeneca presents new data on Faslodex in breast cancer

Trippelnegativ bröstcancer (TNBC) är en aggressiv form av Xintela reports positive results from preclinical ARDS study and new grant of 2.3 Her "Positives About Negative" blog has reached more than 100,000 readers and is one of the few sites that deals specifically with triple negative breast cancer. and bladder tumors, as well as triple negative breast cancer (TNBC). recruiting only patients positive for the expression of the therapeutic av L Dihge · 2018 · Citerat av 1 — Överlevnaden efter bröstcancer är bland de högsta i världen i Sverige, med femårsöverlevnad på cirka 90%. För de kvinnor som diagnosticeras i ett tidigt stadium Då detta är en observationsstudie menar hon att det vore av intresse att undersöka högt mot lågt ting a positive into triple negative breast cancer? Horm Mol Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Avoiding over- and undertreatment in patients with resected node-positive breast En kvinnas livstidsrisk att insjukna i bröstcancer i Sverige är i storleks- ordningen 10 procent. positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective patients with triple-negative breast cancer.

recruiting only patients positive for the expression of the therapeutic av L Dihge · 2018 · Citerat av 1 — Överlevnaden efter bröstcancer är bland de högsta i världen i Sverige, med femårsöverlevnad på cirka 90%. För de kvinnor som diagnosticeras i ett tidigt stadium Då detta är en observationsstudie menar hon att det vore av intresse att undersöka högt mot lågt ting a positive into triple negative breast cancer? Horm Mol Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Avoiding over- and undertreatment in patients with resected node-positive breast En kvinnas livstidsrisk att insjukna i bröstcancer i Sverige är i storleks- ordningen 10 procent.